Translating HIV sequences into quantitative fitness landscapes to predict viral vulnerabilities for rational immunogen design

1Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA, 2Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA 02129, USA, 3HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, and KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), University of KwaZulu-Natal, Durban 4013, South Africa, 4Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA, 5Departments of Chemistry and Physics, MIT, Cambridge, MA 02139, USA.